Acquired TTP: ADAMTS13 meets the immune system
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| Award date | 06-09-2013 |
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| Number of pages | 191 |
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| Abstract | Autoantibodies directed against ADAMTS13 prohibit the processing of VWF multimers, initiating a rare and life-threatening disorder called acquired thrombotic thrombocytopenic purpura (TTP). At present it is not clear why previously healthy individuals develop anti-ADAMTS13 antibodies. The studies described in this thesis aim to increase our understanding of the molecular mechanisms involved in the generation of anti-ADAMTS13 antibodies in patients with acquired TTP. |
| Document type | PhD thesis |
| Note | Research conducted at: Universiteit van Amsterdam |
| Language | English |
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