Characterization of the Myc collaborating oncogenes Bmi1 and Gfi1

Thesis

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Titlepage

Contents

Chapter 1 Introduction

Chapter 2 Characterization of pal-1, a common proviral insertion site in murine leukemia virus-induced lymphomas of c-myc and pim-1 transgenic mice

Chapter 3 Retroviral insertions in the bla1 locus result in long-range activation of the bmi1 proto-oncogene in B cell lymphomas

Chapter 4 Bmi-1 collaborates with c-Mye in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF

Chapter 5 Gfil promotes thymocyte selection at different stages and inhibits death by neglect, during negative selection and in common receptor γ-chain deficient mice

Chapter 6 Chronic Myeloid Leukemia-like syndrome and lymphoblastic T cell tumors in mice transgenic for the transcription factor Gfi1

Chapter 7 Enforced expression of Gfil alters craniofacial and tooth morphogenesis and induces osteoblastic neural crest cell tumors

Chapter 8 Eμ-myc and gfil collaborate in T cell lymphomagenesis by targeting a p53- and Bcl-2-independent apoptosis pathway

Summary & Samenvatting

Abbreviations

Publications

Curriculum Vitae

Dankwoord

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