Processing of apoptotic cells in health and systemic autoimmune disease

Authors	B. Zwart
Supervisors	L.A. Aarden
Award date	30-03-2010
ISBN	9789053352632
Number of pages	163
Organisations	Faculty of Medicine (AMC-UvA)
Document type	PhD thesis
Language	English
Downloads	Thesis Cover Title pages Contents Chapter 1: Introduction Chapter 2: Chromatin-independent binding of serum amyloid P component to apoptotic cells Chapter 3: Binding of the phospholipid-binding plasma proteins, β2-glycoprotein-I, serum amyloid P component and C-reactive protein to apoptotic cells is not defective in SLE Chapter 4: Complement activation by apoptotic cells occurs predominantly by IgM and is limited to late apoptotic (secondary necrotic) cells Chapter 5: Binding of IgG and C1q to late apoptotic cells is increased in SLE plasma : a role for IgG antinuclear antibody (ANA) as activator of complement? Chapter 6: A plasma nucleosome releasing factor (NRF) with serine protease activity is instrumental in removal of nucleosomes from secondary necrotic cells Chapter 7: Nucleosome releasing factor (NRF) activity in plasma from SLE patients Chapter 8: Nucleosome releasing factor : a new role for factor VII-activating protease (FSAP) Chapter 9: General discussion Summary Samenvatting
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