NR4A nuclear receptors in atherosclerosis

Thesis

Title pages

Table of contents

Chapter 1: General introduction

Chapter 2: Nur77 modulates hepatic lipid metabolism through suppression of SREBP-1c activity

Chapter 3: Nuclear receptors Nur77, Nurr1, and NOR-1 expressed in atherosclerotic lesion macrophages reduce lipid loading and inflammatory responses

Chapter 4: Nurr1 is expressed in human in-stent restenosis and reduces neointima hyperplasia by inhibition of smooth muscle cell proliferation and inflammatory gene expression

Chapter 5: Activation of nuclear receptor Nur77 by 6-mercaptopurine protects against neointima formation

Chapter 6: 6-Mercaptopurine induces anti-atherogenic effects in monocytes/macrophages and inhibits atherosclerosis in ApoE*3-Leiden transgenic mice

Chapter 7: General discussion

Summary

Nederlandse samenvatting

List of publications

Curriculum vitae

Dankwoord