Applications and outcomes of gluteal flaps following rectal cancer surgery
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| Award date | 25-10-2024 |
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| Number of pages | 217 |
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| Abstract |
The surgical treatment for patients with rectal cancer is associated with high morbidity, which has a serious impact on quality of life. This thesis aimed to improve postoperative outcomes for rectal cancer patients.
Part I focuses on the applicability of gluteal tissue flaps for preventing and treating pelvic complications. Chapter 3 discusses the use of gluteal fasciocutaneous flaps to treat chronic pelvic sepsis following pelvic surgery. With a high success rate of 89% in perineal wound healing, these flaps are shown to be an effective reconstruction method. Chapter 4 includes a technical note about the use of the gluteal turnover flap for reconstructing the posterior vaginal wall after abdominoperineal resection. Chapter 5 assesses the applicability of the gluteal turnover flap after primary abdominoperineal resection; although the flap did not significantly improve wound healing compared to primary closure, it did significantly lower the risk of presacral abscess (9% vs 22%) and need for drainage. Part II examines the consequences and repair techniques for perineal hernia. Chapter 6 explores how displacement of urogenital organs after abdominoperineal resection affects function, finding that cervix displacement correlates with worse sexual function in women. A symptomatic perineal hernia can significantly worsen quality of life, as revealed in Chapter 7. Chapter 8 presents a systematic review of perineal hernia repair techniques, finding that combined mesh and tissue flap reconstruction has the lowest recurrence rate (9%) compared to biological mesh (39%), synthetic mesh (29%), and tissue flap alone (37%). A comparative multicentre study described in Chapter 9 shows that combining mesh with a gluteal flap for perineal hernia repair results in a lower recurrence rate (14%) compared to mesh-only repairs (34%). This thesis supports the use of gluteal flaps for specific purposes. |
| Document type | PhD thesis |
| Language | English |
| Downloads |
Thesis (complete)
(Embargo up to 2026-10-25)
Chapter 5: Perineal wound closure using gluteal turnover flap or primary closure after abdominoperineal resection for rectal cancer: A randomised controlled multicentre trial (BIOPEX-2 study)
(Embargo up to 2026-10-25)
Chapter 9: Outcomes of perineal hernia repair: A comparison of mesh repair versus mesh combined with gluteal turnover flap
(Embargo up to 2026-10-25)
Chapter 10: Summary
(Embargo up to 2026-10-25)
Chapter 11: General discussion and future perspectives
(Embargo up to 2026-10-25)
Nederlandse samenvatting
(Embargo up to 2026-10-25)
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