Familial hypercholesterolemia in childhood: diagnostics, therapeutical options and risk stratification

Thesis

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Stellingen behorende bij het proefschrift

Titlepage

Contents

General Introduction and Outline of this Thesis

Part I: Diagnostics of familial hypercholesterolemia in children

Chapter 1 Familial hypercholesterolemia in children

Chapter 2 Family history and cardiovascular risk in familial hypercholesterolemia: data in more than 1000 children

Chapter 3 Arterial intima-media thickness in children heterozygous for familial hypercholesterolaemia

Chapter 4 Effect of low-density lipoprotein receptor mutation on lipoproteins and cardiovascular disease risk: a parent-offspring study

Chapter 5 A boy with autosomal recessive hypercholesterolemia

Part II: Therapeutical options in children with familial hypercholesterolemia

Chapter 6 Lipid-Lowering Medications

Chapter 7 The spectrum of statin therapy in hyperlipidemic children

Chapter 8 Efficacy and safety of statin therapy in children with familial hypercholesterolemia: a randomized controlled trial

Chapter 9 Statin treatment in familial hypercholesterolemia: The younger the better

Chapter 10 LDL receptor genotype and response to pravastatin in children with familial hypercholesterolemia: substudy of an intima-media thickness trial

Chapter 11 Plant stanols do not restore endothelial function in pre-pubertal children with familial hypercholesterolaemia despite reduction of total and LDL cholesterol

Part III: Additional risk factors in children with familial hypercholesterolemia

Chapter 12 Levels and size of lipoprotein particles in children with familial hypercholesterolemia

Chapter 13 Oxidized low-density lipoprotein in children with familial hypercholesterolemia and unaffected siblings: the effect of pravastatin

Summary

Samenvatting

Dankwoord

Curriculum Vitae

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