Therapeutic arteriogenesis: from experimental observations towards clinical application [cum laude]

Thesis

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STELLINGEN BIJ HET PROEFSCHRIFT

Titlepage

CONTENTS

1 INTRODUCTION AND OUTLINE: MECHANISMS AND MODULATION OF COLLATERAL ARTERY DEVELOPMENT

2 STIMULATION OF ARTERIOGENESIS: A NEW CONCEPT FOR THE TREATMENT OF ARTERIAL OCCLUSIVE DISEASE

3 DIRECT EVIDENCE FOR TNF-α SIGNALING IN ARTERIOGENESIS

4 CD44 MEDIATES COLLATERAL ARTERY DEVELOPMENT

5 TIME COURSE OF ARTERIOGENESIS FOLLOWING FEMORAL ARTERY OCCLUSION IN THE RABBIT

6 GM-CSF: A STRONG ARTERIOGENIC FACTOR ACTING BY AMPLIFICATION OF MONOCYTE FUNCTION

7 EXOGENOUS APPLICATION OF TRANSFORMING GROWTH FACTOR-BETA 1 STIMULATES ARTERIOGENESIS IN THE PERIPHERAL CIRCULATION

8 INVASIVE AND NON-INVASIVE EVALUATION OF SPONTANEOUS ARTERIOGENESIS IN A NOVEL PORCINE MODEL FOR PERIPHERAL ARTERIAL OBSTRUCTIVE DISEASE

9 MODULATION OF COLLATERAL ARTERY GROWTH INA PORCINE HIND LIMB LIGATION MODEL USING MONOCYTE CHEMOATTRACTANT PROTEIN-1

10 EFFECTS OF LOCAL MCP-1 PROTEIN THERAPY ON THE DEVELOPMENT OF THE COLLATERAL CIRCULATION AND ATHEROSCLEROSIS IN WATANABE HYPERLIPIDEMIC RABBITS

11 LOCAL MONOCYTE CHEMOATTRACTANT PROTEIN-1 THERAPY INCREASES COLLATERAL ARTERY FORMATION IN APOLIPOPROTEIN-E DEFICIENT MICE BUT INDUCES SYSTEMIC MONOCYTIC CD11B EXPRESSION, NEOINTIMA FORMATION AND PLAQUE PROGRESSION

12 DESIGN OF THE START-TRIAL: STIMULATION OF ARTERIOGENESIS USING SUBCUTANEOUS APPLICATION OF GMCSF AS A NEW TREATMENT FOR PERIPHERAL VASCULAR DISEASE, A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL

13 SUMMARY AND CONCLUSIONS

14 SAMENVATTING EN CONCLUSIES

DANKWOORD

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