Neuritogenic activity-guided isolation of a free base form manzamine A from a marine sponge, Acanthostrongylophora aff. ingens (Thiele, 1899)
| Authors |
|
|---|---|
| Publication date | 2008 |
| Journal | Chemical & Pharmaceutical Bulletin |
| Volume | Issue number | 56 | 6 |
| Pages (from-to) | 866-869 |
| Organisations |
|
| Abstract | Two manzamine-class alkaloids, manzamine A (1) and 8-hydroxymanzamine (2) were isolated from a Japanese marine sponge Acanthostrongylophora aff. ingens, together with three known alkaloids manzamine E (3), manzamine F (4), and manzamine X (5). The spectral features of 1 and 2 were different from the reported data. Detailed structure analysis using 2D NMR revealed the structure of 1 and 2 as a free base form of hydrochloric salt. These manzamine-class alkaloids showed neuritogenic activity against Neuro 2a cells. |
| Document type | Article |
| Published at |
https://doi.org/10.1248/cpb.56.866
(Final published version)
|
| Permalink to this page | |