The cell cycle in neuroblastoma : from genomic aberrations to targeted intervention

Authors	J.J. Molenaar
Supervisors	H.N. Caron R Versteeg
Award date	18-09-2009
ISBN	9789090245003
Number of pages	132
Organisations	Faculty of Medicine (AMC-UvA)
Document type	PhD thesis
Language	English
Downloads	Thesis Front cover Title pages Contents Chapter 1: Introduction Chapter 2: Rearrangements and increased expression of Cyclin D1 in neuroblastoma Chapter 3: Cyclin D1 is a direct transcriptional target of GATA3 in neuroblastoma tumor cells Chapter 4: Cyclin D1 and CDK4 activity contribute to the undifferentiated phenotype in neuroblastoma Chapter 5: High frequency of genetic aberrations of G1 regulating cell cycle genes in neuroblastoma is related to high expression of G2/M phase E2F target genes and worse prognosis Chapter 6: Inactivation of CDK2 is synthetically lethal to MYCN over-expressing cancer cells Chapter 7: Discussion and future directions Chapter 8: Nederlandse samenvatting en dankwoord Back cover
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