Glycosphingolipids and atherosclerosis

Glycosphingolipids and atherosclerosis

Authors	E. Lombardo
Supervisors	J.M.F.G. Aerts
Cosupervisors	A.K. Groen F.M.D.F. Bietrix
Award date	02-04-2013
Number of pages	223
Organisations	Faculty of Medicine (AMC-UvA)
Document type	PhD thesis
Note	Research conducted at: Universiteit van Amsterdam
Language	English
Downloads	Thesis Cover Title pages Contents Chapter I: General introduction Chapter II: Inhibition of glycosphingolipid synthesis induces a profound reduction of plasma cholesterol and inhibits atherosclerosis development in APOE*3 Leiden and LDLR-/- mice Chapter III: The beneficial effect of hydrophobic iminosugars on cholesterol excretion is dependent on concomitant inhibition of glucosylceramide synthase and glucocerebrosidase activity Chapter IV: Short term inhibition of glycosphingolipid synthesis does not promote atherosclerosis regression in LDLR(-/-) mice Chapter V: Voluntary wheel running increases bile acid as well as cholesterol excretion and decreases atherosclerosis in hypercholesterolemic mice Chapter VI: Expression of chitotriosidase in atherosclerotic plaque macrophages in mouse models: limited correlation of plasma chitotriosidase with lesions in aortic sinus Chapter VII: Glycosphingolipid synthesis inhibitor AMP-DNM lowers plasma cholesterol levels by promoting faecal cholesterol excretion without inhibiting cholesterol absorption Chapter VIII: Correction of liver steatosis by a hydrophobic iminosugar modulating glycosphingolipids metabolism Chapter IX: Glycosphingolipids and insulin resistance Chapter X: Discussion Summary Samenvatting Acknowledgements
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Glycosphingolipids and atherosclerosis