Genes and surgery in pancreatic cancer

Thesis

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Titlepage

CONTENTS

GENERAL INTRODUCTION

OUTLINE OF THE THESIS

Part I MOLECULAR MARKERS

CHAPTER 1 Micrometastases in bone marrow of patients with suspected pancreatic or ampullary cancer

CHAPTER 2 K-ras, p53, and DPC4 (MAD4) alterations in fine-needle aspirates of the pancreas

CHAPTER 3 Usefulness of conventional cytologic and molecular analyses for detection of peritoneal spread of periampullary cancer

CHAPTER 4 Long-term follow-up of patients with a clinically benign extrahepatic biliary stenosis and K-ras mutation in endobiliary brush cytology

CHAPTER 5 The prevalence of K-ras mutations in ductal brush cytology and bile of subjects without pancreatic disease using the epidemiologic necropsy as study design

CHAPTER 6 Comparison of the novel quantitative ARMS assay and an enriched PCR-ASO assay for K-ras mutations with conventional cytology on endobiliary brush cytology from 312 consecutive extrahepatic biliary stenoses

CHAPTER 7 Telomere shortening is nearly universal in pancreatic intraepithelial neoplasia

CHAPTER 8 Discovery of novel tumor markers of pancreatic cancer using global gene expression technology

CHAPTER 9 Gene expression profiling identifies markers of ampullary adenocarcinoma

Part II MANAGEMENT

CHAPTER 10 Surgical management of neoplasms of the ampulla of Vater: local resection or pancreatoduodenectomy and prognostic factors for survival

CHAPTER 11 Influence of hospital volume on mortality after pancreatic resection: a systematic review

CHAPTER 12 How the surgical community failed to reduce mortality after pancreaticoduodenectomy: ongoing plea for centralization

CHAPTER 13 Palliative treatment in "peri"-pancreatic carcinoma: stenting or surgical therapy?

CHAPTER 14 The need for a prophylactic gastrojejunostomy for unresectable periampullary cancer

SUMMARY AND CONCLUSIONS

SAMENVATTING EN CONCLUSTES

COLOR ILLUSTRATIONS

EPILOGUE

LIST OF PUBLICATIONS

ACKNOWLEDGEMENTS DANKWOORD

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