NR4A nuclear receptors in vascular disease

Thesis

Cover

Title pages

Table of contents

Preface and outline of the thesis

1: General introduction on atherosclerosis and restenosis

2: NR4A nuclear receptors in atherosclerosis and vein graft disease

3: NR4A nuclear orphan receptors : protective in vascular disease?

4: Nuclear receptors Nur77, Nurr1 and NOR-1 expressed in atherosclerotic lesion macrophages reduce lipid loading and inflammatory responses

5: Nuclear receptor Nur77 inhibits carotid artery outward remodeling and reduces macrophage content and matrix metalloproteinase levels

6: 6-mercaptopurine induces anti-atherogenic effects in monocytes/ macrophages and inhibits atherosclerosis in ApoE*3-Leiden transgenic mice

7: Nuclear receptor Nurr1 is expressed in and associates with human restenosis and inhibits vascular lesion formation in mice involving inhibition of smooth muscle cell proliferation and inflammation

8: Activation of nuclear receptor Nur77 by 6-mercaptopurine protects against neointima formation

9: The p27kip1 –838C>A single nucleotide polymorphism is associated with restenosis risk after coronary stenting and modulates p27kip1 promoter activity

10: General discussion

11: Summary & Samenvatting voor niet-ingewijden

List of contributors

List of publications

Dankwoord