Bypassing GPCRs with chemical dimerizers

Authors	J. Goedhart T.W.J. Gadella (jr.)
Publication date	2011
Journal	Chemistry & Biology
Volume | Issue number	18 | 9
Pages (from-to)	1067-1068
Organisations	Faculty of Science (FNWI) - Swammerdam Institute for Life Sciences (SILS)
Abstract	G protein-coupled receptors (GPCRs) activate heterotrimeric G protein complexes. In this issue, Putyrski and Schultz (2011) describe a rapamycin-based system to bypass the GPCR by direct activation of a specific heterotrimeric G protein subunit, which induces downstream signaling cascades.
Document type	Article
Language	English
Published at	https://doi.org/10.1016/j.chembiol.2011.09.004
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