Neurophysiological correlates of the pathway to the early stages of psychosis

Our results indicate that in help-seeking individuals who meet the criteria for ‘at risk mental state’, particular neurophysiological paradigms (i.e. parietal P300 amplitudes and resting state QEEG theta and delta power and individual alpha peak frequency) can contribute to the differentiation between subjects who do or do not convert to psychosis. In contrast, neurophysiological components associated with early processing, including N100 and SPEM parameters, showed changes with psychotic onset. These findings suggest that discernible neurophysiological components behave differently during progression from the prodromal phase to the first psychotic episode. Furthermore, as we found several associations between neurophysiological parameters and severity of UHR symptoms and functional disability, our findings provide further insights into the associations between information processing impairments and clinical as well as functional outcome.