Template-Directed Synthesis of an Inverted Spiro Architecture
| Authors |
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| Publication date | 06-09-2018 |
| Journal | Chemistry-A European Journal |
| Volume | Issue number | 24 | 50 |
| Pages (from-to) | 13114-13117 |
| Number of pages | 4 |
| Organisations |
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| Abstract | The regular bicyclic spiro motif is highly abundant given its synthetic accessibility while the diastereomer-virtually obtained through inversion at the central atom-is almost unknown. We have developed methodology to access the elusive inverted spiro architecture by employing a covalent template-directed approach. Comparison with the regular spiro bicycle analog unequivocally established the diastereomeric relationship, providing insight into the fascinating stereochemical and structural properties. |
| Document type | Article |
| Language | English |
| Published at | https://doi.org/10.1002/chem.201803356 |
| Downloads |
Wanner_et_al-2018-Chemistry_-_A_European_Journal
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