Dilated cardiomyopathy: Translating genetic defects into clinical care. Towards personalized medicine in dilated cardiomyopathy

Thesis

Cover

Title pages

Contents

Chapter 1: Introduction and outline of this thesis

Chapter 2.1: Genetic analysis of 418 index-patients with idiopathic dilated cardiomyopathy: Overview of 10 years’ experience

Chapter 2.2: Phospholamban R14del mutation in patients diagnosed with dilated cardiomyopathy or arrhythmogenic right ventricular cardiomyopathy: Evidence supporting the concept of arrhythmogenic cardiomyopathy

Chapter 3.1: Gender-specific differences in major cardiac events and mortality in lamin A/C mutation carriers

Chapter 3.2: Lamin A/C mutation is independently associated with an increased risk of arterial and venous thromboembolic complications

Chapter 4.1: Risk factors for malignant ventricular arrhythmias in lamin A/C mutation carriers: A European cohort study

Chapter 4.2: Mortality and cardiac disease outcome in phospholamban R14del carriers: Results of a large multicentre cohort study

Summary and future directions

Summary (Dutch)

Curriculum vitae

Acknowledgements