Gracilioethers A-C, Antimalarial Metabolites from the Marine Sponge Agelas gracilis
| Authors |
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| Publication date | 2009 |
| Journal | Journal of Organic Chemistry |
| Volume | Issue number | 74 | 11 |
| Pages (from-to) | 4203-4207 |
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| Abstract | Three new antiprotozoan compounds, gracilioethers A−C (1−3), have been isolated from the marine sponge Agelas gracilis. Their structures were elucidated on the basis of spectroscopic and chemical methods. Gracilioethers A−C showed antimalarial activity against Plasmodium falciparum with IC50 values of 0.5−10 μg/mL, whereas gracilioether B (2) also showed antileishmanial activity. |
| Document type | Article |
| Language | English |
| Published at |
https://doi.org/10.1021/jo900380f
(Final published version)
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