Targeting CD47-SIRPα interactions for potentiating therapeutic antibody-mediated tumor cell destruction by phagocytes
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| Award date | 02-07-2014 |
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| Number of pages | 149 |
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| Abstract | The primary aim of the studies described in this thesis was to investigate the role of CD47-SIRPα interactions in therapeutic antibody-dependent tumor cell destruction by human phagocytes and also explore the killing mechanism(s) by which human phagocytes, and in particular human neutrophils, mediate therapeutic antibody-dependent cytotoxicity towards cancer cells. |
| Document type | PhD thesis |
| Note | Research conducted at: Sanquin Research and Landsteiner Laboratory AMC |
| Language | English |
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