The stress-axis in multiple sclerosis. Effects of sepsis, morphine and corticosteroids

Thesis

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Titlepage

Table of Contents

CHAPTER I General Introduction

CHAPTER II Increased activity of hypothalamic corticotropin-releasing hormone (CRH) neurons in multiple sclerosis

CHAPTER III Impaired HPA-axis activity and more severe multiple sclerosis (MS) with hypothalamic lesions

CHAPTER IV Cortisol is increased in postmortem cerebrospinal fluid of multiple sclerosis patients: relationship with cytokines and sepsis

CHAPTER V Stress of dying is not suppressed by high-dose morphine or by dementia

CHAPTER VI Glucocorticoids suppress corticotropin-releasing hormone and vasopressin expression in human hypothalamic neurons

CHAPTER VII Glucocorticoid treatment is associated with decreased expression of processed AVP but not of proAVP, neurophysin or oxytocin in the human hypothalamus: Are PC1 and PC2 involved?

CHAPTER VIII IL-1β immunoreactive neurons in the human hypothalamus: reduced numbers in multiple sclerosis

CHAPTER IX General Discussion

LIST OF FRQUENTLY USED ABBREVIATIONS

ADDRESSES AND AFFILIATIONS OF THE AUTHORS OF THE CHAPTERS

SUMMARY

SAMENVATTING

DANKWOORD

CURRICULUM VITAE

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