| Abstract |
Lysine acylation is a rapidly growing field with a wide range of novel acylation modifications and a huge number of target proteins being identified. There are indications that these new modifications have functional roles in the regulation of cellular metabolism, however due to their novelty, little is known about the actual mechanisms. The aim of this thesis is to understand the physiological relevance of different protein acylation modifications in the regulation of cellular metabolism and to elucidate its role in inherited metabolic diseases.
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