IL-1β and mevalonate kinase deficiency

Authors	S.H.L. Mandey
Supervisors	R.J.A. Wanders
Cosupervisors	H.R. Waterham J. Frenkel
Award date	15-02-2008
Number of pages	111
Organisations	Faculty of Medicine (AMC-UvA)
Document type	PhD thesis
Note	Research conducted at: Universiteit van Amsterdam
Language	English
Downloads	Thesis Cover Titlepage Contents Abbreviations Chapter 1 General Introduction: an overview of the isoprenoid biosynthesis pathway and its defects with emphasis on mevalonate kinase deficiency Chapter 2 Mutational spectrum and genotype-phenotype correlations in mevalonate kinase deficiency Chapter 3 Cytokine and chemokine profiles in mevalonate kinase deficiency Chapter 4 A role for geranylgeranylation in interleukin-1β secretion Chapter 5 The effect of simvastatin on the LPS-stimulated secretion of IL-1β by THP-1 cells Chapter 6 Lack of isoprenoid products raises ex-vivo IL-1 secretion in HIDS Summary & samenvatting voor iedereen Dankwoord
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