Optical methods for the assessment of microvascular perfusion and oxygenation

Thesis

Front cover

Title pages

Contents

General introduction

Outline of the thesis

Chapter 1: Sidestream dark field imaging: a novel microscopic modality for clinical assessment of the microcirculation

Chapter 2: Improvement of sidestream dark field imaging with an image acquisition stabilizer

Chapter 3: Rapid automatic quantification of microvascular density in sidestream dark field images

Chapter 4: Validation of laser speckle imaging for assessing microvascular (re)perfusion by comparison to sidestream dark field imaging

Chapter 5: Laser speckle imaging for real-time assessment of renal microvascular perfusion heterogeneities

Chapter 6: Multi-level phosphorimetry for studying microvascular and interstitial oxygen tensions in the renal cortex and medulla during endotoxemia

Chapter 7: Validation of phosphorimetry for assessing microvascular oxygen tension heterogeneities

Chapter 8: Combined laser speckle imaging and phosphorimetry for studying the role of renal hypoperfusion in the development of renal microcirculatory dysfunction in endotoxemic rats

Summary and conclusions

Samenvatting en conclusies

References

Acknowledgements

Curriculum vitae

List of publications