The quest for biomarkers: Computational exploration of the cancer genome

Authors	J.J. de Ronde
Supervisors	S. Rodenhuis L.F.A. Wessels
Award date	02-07-2013
ISBN	9789461823007
Number of pages	275
Organisations	Faculty of Medicine (AMC-UvA)
Document type	PhD thesis
Note	Research conducted at: Universiteit van Amsterdam
Language	English
Downloads	Thesis Cover Title pages Table of contents Introduction Chapter 1: Gene expression profiles from formalin-fixed, paraffin embedded material are comparable to profiles from fresh frozen matched material Chapter 2: 2.1: Concordance of clinical and molecular breast cancer subtyping in the context of preoperative chemotherapy response; 2.2: Molecular subtyping of breast cancer: Ready to use? Chapter 3: Breast cancer subtype specific classifiers of response to chemotherapy do not outperform classifiers trained on all subtypes Chapter 4: Identifying subgroup markers in heterogeneous populations Chapter 5: SERPINA6, BEX1, AGTR1, SLC26A3, and LAPTM4B are markers of resistance to neoadjuvant chemotherapy in HER2-negative tumors Chapter 6: KC-SMARTR: An R package for detection of statistically significant aberrations in multi-experiment aCGH data Chapter 7: Selection of patients for hepatic surgery of colorectal cancer liver metastasis based on genomic aberrations Chapter 8: The mutational landscape of four breast tumors, before and after chemotherapeutic intervention Discussion Summary Samenvatting List of publications Curriculum vitae PhD portfolio Dankwoord Stellingen
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