Studies on leptospirosis : clinical aspects and pathophysiology

Thesis

Cover

Titlepage

Contents

Chapter 1: General Introduction and outline of the thesis

Chapter 2: What role do coagulation disorders play in the pathogenesis of leptospirosis?

Chapter 3: Leptospirosis with pulmonary hemorrhage, caused by a new strain of serovar Lai: Langkawi.

Chapter 4: Coagulation disorders in patients with severe leptospirosis are associated with severe bleeding and mortality.

Chapter 5: Bleeding in patients with severe leptospirosis is not associated with activation of endothelial cells.

Chapter 6: Low factor XII and factor XI levels in patients with severe leptospirosis.

Chapter 7: Long pentraxin PTX3 is associated with mortality and disease severity in severe leptospirosis.

Chapter 8: Soluble ST2 levels are associated with bleeding in patients with severe leptospirosis.

Chapter 9: Innate immune response to pathogenic leptospira is dependent of both TLR2 and TLR4 signaling in human whole blood.

Chapter 10: Rapid serologic assays for leptospirosis are of limited value in southern Vietnam.

Chapter 11: Murine typhus and leptospirosis as a cause of acute undifferentiated fever in Central Java, Indonesia.

Chapter 12: Summary, discussion and directions for future studies

Samenvatting en discussie voor niet-ingewijden

Dankwoord

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