The role of abca1 in atherosclerosis: lessons from in vitro and in vivo models

Thesis

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Titlepage

Contents

Chapter 1 Introduction

PART I: Insights from an abca1 animal model

Chapter 2 Human ABCA1 BAC transgenic mice show increased HDL-C and ApoAl dependant efflux stimulated by an internal promoter containing Liver X Receptor Response elements in intron 1

Chapter 3 Alternate transcripts expressed in response to diet reflect tissue specific regulation of ABCA1

Chapter 4 Increased ABCA1 activity protects against atherosclerosis

Chapter 5 Macrophage ABCA1 over-expression inhibits atherosclerotic lesion progression

Chapter 6 Alterations of plasma lipids in mice via adenoviral mediated hepatic overexpression of human ABCA1

PART II: In-vitro studies of abca1 function

Chapter 7 Efflux and Atherosclerosis: The clinical and biochemical impact of variations in the ABCA1 gene

Chapter 8 The variation of phenotypes in Tangier Disease and FHA is directly influenced by the nature of DNA changes in ABCA1

Chapter 9 Identification and Functional Analysis of a Naturally Occurring E89K Mutation in the ABCA1 Gene of the WHAM chicken

Chapter 10 Truncation mutations in ABCA1 suppress normal upregulation of full-length ABCA1 by 9-cis-retinoic acid and 22-r-hydroxycholesterol

Chapter 11 Discussion

Curriculum vitae

Acknowledgements

Samenvatting

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