No effect of prolonged corticosterone over-exposure on NCAM, SGK1, and RGS4 mRNA expression in rat hippocampus
| Authors |
|
|---|---|
| Publication date | 2006 |
| Journal | Brain Research |
| Volume | Issue number | 1093 | 1 |
| Pages (from-to) | 161-166 |
| Organisations |
|
| Abstract | Prolonged over-exposure of rats to corticosterone attenuates 5-HT(1A)-receptor-mediated responses in hippocampal CA1 cells through an unknown mechanism, not involving downregulation of 5-HT(1A) receptor expression. We here tested if corticosterone changes 5-HT(1A) receptor function indirectly, by altering hippocampal mRNA expression of NCAM, SGK1, or RGS4, which all modulate 5-HT(1A) receptor function. We found that the expression of none of these candidates was affected by corticosterone treatment. |
| Document type | Article |
| Language | English |
| Published at |
https://doi.org/10.1016/j.brainres.2006.03.083
(Final published version)
|
| Permalink to this page | |