Ligand‐Enabled γ‐C(sp3)–H Acetoxylation of Triflyl‐Protected Amines
| Authors | |
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| Publication date | 02-12-2018 |
| Journal | European Journal of Organic Chemistry |
| Volume | Issue number | 2018 | 44 |
| Pages (from-to) | 6088-6091 |
| Number of pages | 4 |
| Organisations |
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| Abstract | A palladium‐catalyzed γ‐C(sp3)–H acetoxylation of triflyl‐protected amines has been achieved. The use of pyridine or 2‐alkoxyquinoline‐type ligands is key to the success of this transformation. The reaction is highly diastereoselective and easily scalable, and constitutes a direct approach for the synthesis of γ‐hydroxy‐α‐amino acids and β,γ‐dihydroxy amines, which are not readily accessible by other routes. |
| Document type | Article |
| Note | - Special Issue: C‐H Activation in Organic Synthesis - With supplementary file |
| Language | English |
| Published at | https://doi.org/10.1002/ejoc.201800891 |
| Downloads |
Jia_et_al-2018-European_Journal_of_Organic_Chemistry
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