Controlled light exposure microscopy reveals telomeric microterritories throughout the cell cycle

Authors
  • P. van Oostveldt
Publication date 2008
Host editors
  • A. Aretz
  • B. Hermanns-Sachweh
  • J. Mayer
Book title EMC 2008: 14th European Microscopy Congress, 1-5 September 2008, Aachen, Germany: Volume 3: Life science
ISBN
  • 9783540852278
Event 14th European Microscopy Congress (EMC 2008), Aachen, Germany
Pages (from-to) 169-170
Publisher Berlin: Springer
Organisations
  • Faculty of Science (FNWI) - Swammerdam Institute for Life Sciences (SILS)
  • Faculty of Medicine (AMC-UvA)
Abstract Telomeres are the natural ends of linear chromosomes. In mammalian cells they consist of a double stranded array of simple TTAGGG repeats ending in a single stranded overhang that folds back to form a T-loop structure [1]. In combination with sufficient telomere repeats, a telosome complex of indirect and direct telomere binding proteins, dubbed shelterin, assures proper telomere function [2]. Telomeres confer structural integrity and positional stability to human chromosomes [3].
Document type Conference contribution
Published at https://doi.org/10.1007/978-3-540-85228-5_85
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