Neural regulation of innate and adaptive immunity in the gut

Neural regulation of innate and adaptive immunity in the gut

Authors	S. Dhawan
Supervisors	W.J. de Jonge
Cosupervisors	R.M.J.G.J. van den Wijngaard
Award date	12-01-2017
ISBN	9789462955462
Number of pages	189
Organisations	Faculty of Medicine (AMC-UvA)
Abstract	This thesis investigates the role of neurotransmitters acetylcholine (ACh) and norepinephrine (NE), in modulating the innate and adaptive immune function in the intestine, during physiological and pathophysiological conditions. Furthermore, this thesis attempts to advance our current understanding of the gut-brain immune axis, also known as the cholinergic anti-inflammatory pathway, coined largely due to the cholinergic nature of the vagus nerve.
Document type	PhD thesis
Language	English
Downloads	Thesis (complete) Front matter Chapter 1: Outline of the thesis Chapter 2: Cholinergic signalling in gut immunity Chapter 3: Mast cells trigger epithelial barrier dysfunction, bacterial translocation and postoperative ileus in a mouse model Chapter 4: Cholinergic receptor activation on epithelia protects against cytokine-induced barrier dysfunction Chapter 5: Adrenergic β2 receptor activation stimulates anti-inflammatory properties of dendritic cells in-vitro Chapter 6: Acetylcholine producing T-cells in the intestine affect antimicrobial peptide expression and microbial diversity Chapter 7: Acetylcholine signalling in T cells in the intestinal mucosa in inflammatory bowel disease patients Chapter 8: Discussion Chapter 9: Appendices: English summary \| Nederlandse samenvatting \| List of abbreviations \| Contributing authors \| Publications \| Dankwoord
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Neural regulation of innate and adaptive immunity in the gut