Enantioselective organocatalytic thiol addition to alpha,beta-unsaturated alpha-amino acid derivatives
| Authors |
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| Publication date | 2012 |
| Journal | Synlett |
| Volume | Issue number | 23 | 15 |
| Pages (from-to) | 2195-2200 |
| Organisations |
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| Abstract |
A new class of Michael acceptors based on α,β-unsaturated amino acids has been prepared and applied in asymmetric organocatalysis. With the use of thiourea derivatives of cinchona alkaloid-derived catalysts, efficient addition of thiols to the dehydroamino acids occurred with formation of β-thiol functionalized α-amino acids in high yields, moderate diastereoselectivities and ee values up to 95%. |
| Document type | Article |
| Language | English |
| Published at |
https://doi.org/10.1055/s-0032-1317081
(Final published version)
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