The molecular mechanism of Atp8b1-deficiency

Authors	A. Groen
Supervisors	R.P.J. Oude Elferink
Cosupervisors	C.C. Paulusma
Award date	08-04-2009
ISBN	9789090239651
Number of pages	158
Organisations	Faculty of Medicine (AMC-UvA)
Document type	PhD thesis
Language	English
Downloads	Thesis Front cover Title pages Table of contents Chapter 1: General introduction Chapter 2: A mouse genetic model for familial cholestasis caused by Atp8b1 mutations reveals perturbed bile salt homeostasis but no impairment in bile secretion Chapter 3: Increased serum concentrations of secondary bile salts during cholate feeding are due to coprophagy : a study with wild-type and Atp8b1-deficient mice Chapter 4: Intestinal bile salt absorption in Atp8b1 deficient mice Chapter 5: Atp8b1 deficiency in mice reduces resistance of the canalicular membrane to hydrophobic bile salts and impairs bile salt transport Chapter 6: Enhanced biliary cholesterol output in Atp8b1 mutant mice is Abcg5/Abcg8 independent Chapter 7: Bile formation in mice lacking both Atp8b1 and Abcb4 Chapter 8: Summary and perspectives Chapter 9: Samenvatting Abbreviations Dankwoord
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