| Authors |
|
| Publication date |
2014
|
| Journal |
Chemistry - A European Journal
|
| Volume | Issue number |
20 | 35
|
| Pages (from-to) |
10905-10909
|
| Organisations |
-
Faculty of Science (FNWI) - Van 't Hoff Institute for Molecular Sciences (HIMS)
|
| Abstract |
The direct dehydrative activation of allylic alcohols and subsequent cross-coupling with alkenes by using palladium catalyst containing a phosphoramidite ligand is described. The activation of the allyl alcohol does not require stoichiometric additives, thus allowing clean, wastefree reactions. The scope is demonstrated by application of the protocol to a series allylic alcohols and vinyl arenes, leading to variety of 1,4-diene products. Based on kinetic studies, a mechanism is proposed that involves a palladium hydride species that activates the allyl alcohol to form the allyl intermediate.
|
| Document type |
Article
|
| Note |
With supporting information
|
| Language |
English
|
| Published at |
https://doi.org/10.1002/chem.201404026
|
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