B cell biology and the development of mature B cell lymphomas

B cell biology and the development of mature B cell lymphomas

Authors	R.J. Bende
Supervisors	C.J.M. van Noesel
Award date	08-04-2010
Number of pages	225
Organisations	Faculty of Medicine (AMC-UvA)
Document type	PhD thesis
Language	English
Downloads	Thesis Front cover Title pages Contents Chapter 1: General Introduction and outline of this thesis Chapter 2: Follicular dendritic cells catalyze hepatocyte growth factor (HGF) activation in the germinal center microenvironment by secreting the serine protease HGF activator Chapter 3: Germinal centers in human lymph nodes contain reactivated memory B cells Chapter 4: Among B cell non-Hodgkin's lymphomas, MALT lymphomas express a unique antibody repertoire with frequent rheumatoid factor reactivity Chapter 5: The majority of cutaneous marginal zone B cell lymphomas express class switched immunoglobulins and develop in a T helper type 2 inflammatory environment Chapter 6: Immunological and genetic characterization of ocular adnexal marginal zone B cell lymphoma Chapter 7: Overview and discussion : chronic inflammatory disease, lymphoid tissue neogenesis and extranodal marginal zone B cell lymphomas Chapter 8: Variable heavy chain gene analysis of follicular lymphomas : correlation between heavy chain isotype expression and somatic mutation load Chapter 9: Variable heavy-chain gene analysis of follicular lymphomas : subclone selection rather than clonal evolution over time Chapter 10: In situ analysis of the variable heavy chain gene of an IgM/IgG-expressing follicular lymphoma : evidence for interfollicular trafficking of tumor cells Chapter 11: Expression of activation-induced cytidine deaminase is confined to B-cell non-Hodgkin's lymphomas of germinal-center phenotype Chapter 12: Primary follicular lymphoma of the small intestine : alpha4beta7 expression and immunoglobulin configuration suggest an origin from local antigen-experienced B cells Chapter 13: Overview and discussion : molecular pathways in follicular lymphoma Chapter 14: Immunoglobulin diversification in B cell malignancies : internal splicing of heavy chain variable region as a by-product of somatic hypermutation Chapter 15: Discussion Summary / Samenvatting Terugblik en dankwoord List of publications
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B cell biology and the development of mature B cell lymphomas