Individual susceptibility to chronic irritant contact dermatitis

Thesis

Cover

Titlepage

Contents

List of Abbreviations

Chapter 1 General Introduction

Chapter 2.1 Variation in barrier impairment and inflammation of human skin as determined by sodium lauryl sulphate penetration rate

Chapter 2.2 Percutaneous penetration of sodium lauryl sulphate is increased in uninvolved skin of patients with atopic dermatitis compared with control subjects

Chapter 3.1 Cytokines at different stratum corneum levels in normal and sodium lauryl sulphate-irritated skin

Chapter 3.2 Stratum corneum cytokines and skin irritation response to sodium lauryl sulphate

Chapter 3.3 Differential cytokine expression in skin after single and repeated irritation by sodium lauryl sulphate

Chapter 4.1 Polymorphisms in the interleukin-1 gene influence the stratum corneum interleukin-1α concentration in uninvolved skin of patients with chronic irritant contact dermatitis

Chapter 4.2 Cytokine gene polymorphisms and susceptibility to chronic irritant contact dermatitis

Chapter 4.3 Loss-of-function polymorphisms in the filaggrin gene and susceptibility to chronic irritant contact dermatitis

Chapter 5 General Discussion

Summary

Samenvatting

Dankwoord

Curriculum Vitae