Stereoselective C-terminal peptide elongation from Chan-Lam-Evans reaction generated isopropenyl esters
| Authors | |
|---|---|
| Publication date | 28-02-2019 |
| Journal | Organic & Biomolecular Chemistry |
| Volume | Issue number | 17 | 8 |
| Pages (from-to) | 2103-2106 |
| Number of pages | 4 |
| Organisations |
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| Abstract | C-Terminal dipeptide isopropenyl esters were synthesised by a Cu(II)-mediated Chan-Lam-Evans enol esterification of peptide carboxylic acids and isoprenyl boroxine. These shelf stable peptide esters could be coupled stereoselectively with a variety of amino acid and dipeptide nucleophiles in high yield and purity in the presence of pyrazole/DBU as the catalyst. |
| Document type | Article |
| Note | - Part of collection: Chemical biology in OBC. - With supplementary file |
| Language | English |
| Published at | https://doi.org/10.1039/c8ob02102c |
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