Clinicopathological outcome and prognostication in pancreatic surgery

This thesis mainly encompasses studies aimed to improve oncological and surgical treatment of pancreatic head cancer and other periampullary cancers in relation to short-term clinical and long-term oncological outcome. Many studies are a collaboration between multiple centers, either within the nationwide Dutch Pancreatic Cancer Group (DPCG) or as international collaboration, both within or outside Europe. Part I comprises three chapters, outlining the surgical and oncological outcomes of pancreatic surgery in a single-center study, a nationwide study and an international cohort study. The five chapters in Part II mainly focus on the challenges encountered in the pathology assessment of a surgical specimen following pancreatic surgery. The five chapters in Part III evaluate the prognostic significance of several prediction models and staging systems for pancreatic and other periampullary cancers. The prediction models were made available on the website www.pancreascalculator.com.