Dose-escalation in the picture : pharmacological and imaging studies in depression

Thesis

Cover

Title pages

Contents

Chapter 1: General introduction and outline of the thesis

Chapter 2: Design and methods of the DELPHI-study

Chapter 3: Clinical use of the Hamilton Depression Rating Scale : is increased efficiency possible? A post hoc comparison of HDRS, Maier and Bech subscales, CGI and SCL-90 scores

Chapter 4: Dose-escalation for insufficient response to a standard dose of a selective serotonin reuptake inhibitor in major depressive disorder : a systematic review

Chapter 5: Switching antidepressants after a first selective serotonin reuptake inhibitor in major depressive disorder : a systematic review

Chapter 6: Mood is indirectly related to serotonin, norepinephrine and dopamine levels in humans : a meta-analysis of monoamine depletion studies

Chapter 7: Serotonin transporter binding with [123I]ß-CIT SPECT in major depressive disorder versus controls : effect of season and gender

Chapter 8: Serotonin transporter gene promoter polymorphisms modify the association between paroxetine serotonin transporter occupancy and clinical response in major depressive disorder

Chapter 9: Evidence why paroxetine dose-escalation is not effective in major depressive disorder : a randomized-controlled trial with assessment of serotonin transporter occupancy

Chapter 10: Successful pharmacological treatment of major depressive disorder attenuates amygdala activation to negative facial expressions : an fMRI study

Chapter 11: Effect of the selective serotonin reuptake inhibitor paroxetine on platelet function is modified by a SLC6A4 serotonin transporter polymorphism

Chapter 12: Summary, conclusions and general discussion

Chapter 13: Samenvatting en conclusies

Abbreviations

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Dankwoord

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