The role of antigen in the development of B-cell chronic lymphocytic leukemia
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| Award date | 08-05-2013 |
| Number of pages | 151 |
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| Abstract | These studies strongly suggest that MALT-lymphomas and M-CLL in majority are highly selected for single extrinsic antigens and that these antigens can be both self-antigens and exo-antigens. Our finding that primary CLL cells are responsive to stimulation with their cognate antigen suggests that antigen-dependent BCR signaling may drive CLL expansion in vivo. |
| Document type | PhD thesis |
| Note | Research conducted at: Universiteit van Amsterdam |
| Language | English |
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