The HIV-1 RNA genome and regulation of reverse transcription and polyadenylation

Thesis

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TABLE OF CONTENTS

CHAPTER 1 GENERAL INTRODUCTION

CHAPTER 2 A CONSERVED HAIRPIN MOTIF IN THE R-U5 REGION OF THE HUMAN IMMUNODEFICIENCY VIRUS TYPE-1 RNA GENOME IS ESSENTIAL FOR REPLICATION

CHAPTER 3 INHIBITION OF POLYADENYLATION BY STABLE RNA SECONDARY STRUCTURE

CHAPTER 4 THE ABILITY OF THE HIV-1 AAUAAA SIGNAL TO BIND POLYADENYLATION FACTORS IS CONTROLLED BY LOCAL RNA STRUCTURE

CHAPTER 5 THE EFFECT OF TEMPLATE RNA STRUCTURE ON ELONGATION BY HIV-1 REVERSE TRANSCRIPTASE

CHAPTER 6 FOLDING OF THE HIV-1 MINUS-STRAND STRONG STOP DNA MOLECULE STIMULATES THE FIRST STRAND TRANSFER REACTION OF REVERSE TRANSCRIPTION

CHAPTER 7 SUMMARY AND DISCUSSION

CHAPTER 8 REFERENCE LIST

CHAPTER 9 SAMENVATTING

ACKNOWLEDGEMENTS/ DANKWOORD

CURRICULUM VITAE

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