Aggressive lipid lowering in patients with familial hypercholesterolaemia

Thesis

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Stellingen behorende bij het proefschrift

Titlepage

Contents

1 Intoduction

2 Rationale, design and baseline characteristics of the Atorvastatin versus Simvastatin on Atherosclerosis Progression (ASAP) Study

3 Effect of aggressive versus conventional lipid lowering on atherosclerosis progression in familial hypercholesterolaemia (ASAP): a prospective, randomised, double-blind trial

4 Differential hs-CRP reduction in patients with familial hypercholesterolaemia treated with aggressive or conventional statin therapy

5 Toll-like receptor-4 polymorphism and progression of atherosclerosis in patients with familial hypercholesterolaemia

6 Raised serum levels of soluble CD40 ligand in patients with familial hypercholesterolaemia, Down-regulatory effect of statin therapy

7 Effect of atorvastatin 80 mg and simvastatin 40 mg on plasma fibrinogen levels and on carotid intima-media thickness in patients with familial hypercholesterolaemia

8 The effects of atorvastatin and simvastatin on high density lipoprotein composition in patients with familial hypercholesterolaemia

9 Long-term statin treatment reduces lipoprotein (a) levels in FH heterozygotes

10 The significance of femoral intima-media thickness and plaque scoring in the Atorvastatin versus Simvastatin Atherosclerosis Progression (ASAP) study

11 Long-term safety and efficacy of high dose statin treatment in patients with familial hypercholesterolaemia, The ASAP-extension study

12 Summary and general discussion

Samenvatting

Dankwoord

Curriculum vitae

Abbreviations

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