A close-up of colon cancer

A close-up of colon cancer

Authors	J. Heijmans
Supervisors	G.R. van den Brink D.W. Hommes
Cosupervisors	V. Muncan
Award date	31-10-2013
ISBN	9789090277530
Number of pages	209
Organisations	Faculty of Medicine (AMC-UvA)
Abstract	Understanding development of colorectal cancer requires knowledge on homeostasis of the normal intestinal epithelium as well as intestinal tumorigenesis. In the current thesis, a number of aspects of these two intricately connected subjects are further discussed.
Document type	PhD thesis
Note	Research conducted at: Universiteit van Amsterdam
Language	English
Downloads	Thesis Front cover Title pages Table of contents Chapter 1: Preface: A close-up of colon cancer Chapter 2: General introduction Chapter 3: Blimp1 regulates the transition of neonatal to adult intestinal epithelium Chapter 4: ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response Chapter 5: Loss of Indian hedgehog activates multiple aspects of a wound healing response in the mouse intestine Chapter 6: Intestinal tumorigenesis is not affected by progesterone signaling in rodent models Chapter 7: Gender disparity in colonic tumorigenesis depends on male hormone tumor promotion, not female hormone protection Chapter 8: Oestrogens promote tumorigenesis in a mouse model for colitis-associated cancer Chapter 9: Rage signalling promotes intestinal tumourigenesis Chapter 10: Discussion Summary Nederlandse samenvatting List of abbreviations Dankwoord
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A close-up of colon cancer