A holistic approach for perfusion assessment in septic shock: Basic foundations and clinical applications

Thesis

Cover

Title pages

Table of contents

Introduction: Background & outline

Chapter 1: The holistic view on perfusion monitoring in septic shock

Chapter 2: Microcirculation in sepsis: New perspectives

Chapter 3: Persistent sepsis-induced hypotension without hyperlactatemia: Is it really septic shock?

Chapter 4: Persistent sepsis-induced hypotension without hyperlactatemia: A disctint clinical and physiological profile within the spectrum of septic shock

Chapter 5: Severe abnormalities in microvascular perfused vessel density are associated to organ dysfunctions and mortality, and can be predicted by hyperlactatemia and norepinephrine requirements in septic shock patients

Chapter 6: Impact of emergency intubation on central venous oxygen saturation in critically ill patients: A multicenter observational study

Chapter 7: Evolution of peripheral versus metabolic perfusion parameters during septic shock resuscitation: A clinical-physiologic study

Chapter 8: Sublingual microcirculatory changes during high-volume hemofiltration in hyperdynamic septic shock patients

Chapter 9: Relationship of systemic, hepatosplanchnic, and microcirculatory perfusion parameters with six-hour lactate clearance in hyperdynamic septic shock patients: An acute clinical-physiological, pilot study

Chapter 10: Perfusion parameters exhibit markedly different recovery time courses throughout resuscitation in a cohort of septic shock survivors

Chapter 11: Effects of dobutamine on systemic, regional and microcirculatory perfusion parameters in septic shock: A randomized, placebo-controlled, double-blind, crossover study

Summary and conclusions

Samenvatting en conclusies

Acknowledgments

Curriculum vitae

List of publications