Colon cancer heterogeneity: Stem cells, signals and subtypes

Authors	F. De Sousa E Melo
Supervisors	J.P. Medema
Cosupervisors	L. Vermeulen
Award date	24-09-2013
ISBN	9789461823267
Number of pages	203
Organisations	Faculty of Medicine (AMC-UvA)
Document type	PhD thesis
Note	Research conducted at: Universiteit van Amsterdam
Language	English
Downloads	Thesis Cover Title pages Table of contents Preface Chapter 1: Cancer heterogeneity: A multifaceted view Chapter 2: Single cell cloning of colon cancer stem cells reveals multi-lineage differentiation capacity Chapter 3: Wnt activity defines colon cancer stem cells and is regulated by the microenvironment Chapter 4: The developing cancer stem cell model: Clinical challenges and opportunities Chapter 5: Methylation of cancer-stem-cell-associated Wnt target genes predicts poor prognosis in colorectal cancer patients Chapter 6: Poor prognosis colon cancer is defined by a molecular distinct subtype and develops from serrated precursor lesions Addendum to chapter 6: Colon cancer heterogeneity: From difference to unanimity Chapter 7: Outlook French summary: Cellules souches cancéreuses et futures modalités thérapeutiques du cancer Nederlandse samenvatting Acknowledgements Curriculum vitae Portfolio proefschrift List of publications
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