- Rapid mechanisms of DBS in OCD
- Award date
- 21 October 2016
- Number of pages
- Document type
- PhD thesis
- Faculty of Medicine (AMC-UvA)
Deep brain stimulation (DBS) for therapy-refractory obsessive-compulsive disorder (OCD) patients is capable of improving psychiatric symptoms within seconds to minutes following stimulation initiation. This extraordinary response enticed my interest in exploring the underlying mechanism of DBS for OCD. The main aim of this thesis was to investigate the rapidity of the DBS response as well as various potential working mechanisms. We used clinician rated questionnaires and visual analogue scoring for assessing clinical symptom response, peripheral plasma and urine measures to investigate involvement of the hypothalamic-pituitary-adrenal (HPA)-axis, other neuroendocrine mechanisms and the immune system, and nuclear imaging (SPECT) for investigating striatal dopamine. As our aim was to generate hypothesis we focused on characterizing and possibly linking of the different pathways with each other in connection with clinical symptoms and the cortical-striatal circuit.
- Research conducted at: Universiteit van Amsterdam
If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library, or send a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible.