Background. In patients with psychotic disorders, the effects of psychological post-traumatic stress disorder (PTSD) treatment
on symptoms of psychosis, depression and social functioning are largely unknown
Method. In a single-blind randomized
controlled trial (RCT) 155 outpatients in treatment for psychosis (61.3% schizophrenic disorder, 29% schizoaffective disorder)
were randomized to eight sessions prolonged exposure (PE; n = 53) or eye movement desensitization and reprocessing (EMDR)
(n = 55), or a waiting-list condition (WL, n = 47) for treatment of their co-morbid PTSD. Measures were performed on (1) psychosis:
severity of delusions (PSYRATS-DRS), paranoid thoughts (GPTS), auditory verbal hallucinations (PSYRATS-AHRS), and remission
from psychotic disorder (SCI-SR-PANSS); (2) depression (BDI-II); (3) social functioning (PSP). Outcomes were compared at baseline,
post-treatment, 6-month follow-up and over all data points.
Results. Both PE and EMDR were significantly associated
with less severe paranoid thoughts post-treatment and at 6-month follow-up, and with more patients remitting from schizophrenia,
at post-treatment (PE and EMDR) and over time (PE). Moreover, PE was significantly associated with a greater reduction of
depression at post-treatment and at 6-month follow-up. Auditory verbal hallucinations and social functioning remained unchanged.
In patients with chronic psychotic disorders PE and EMDR not only reduced PTSD symptoms, but also paranoid thoughts. Importantly,
in PE and EMDR more patients accomplished the status of their psychotic disorder in remission. Clinically, these effects are
highly relevant and provide empirical support to the notion that delivering PTSD treatment to patients with psychotic disorders
and PTSD deserves increasing recognition and acceptance among clinicians.