- Optimization of treatment protocols to prevent de novo development of antibiotic resistance in Pseudomonas aeruginosa
- Award date
- 31 October 2016
- Number of pages
- Document type
- PhD thesis
- Faculty of Science (FNWI)
- Swammerdam Institute for Life Sciences (SILS)
The ever-increasing rate of drug resistant bacteria has been one of the most challenging problem worldwide. This thesis studied the following subjects with mostly the clinically leading pathogen, P. aeruginosa, as the model strain: de novo development of antibiotic resistance in patient during the treatment, the influences of the therapy failure of an initial antibiotic treatment on the therapeutic effects of subsequent treatments, the dynamics of mutations during development of resistance by bacteria against the commonly used antibiotics in hospitals, and the optimal ways to administrate drugs in order to cure the infection and at the same time maximally reduce the occurrence of antibiotic resistance.
- Research conducted at: Universiteit van Amsterdam
Thesis (complete) (Embargo until 31 October 2018)
Chapter 5: Optimization of therapy against Pseudomonas aeruginosa with ceftazidime and meropenem using chemostats as model for infections (Embargo until 31 October 2018)
Chapter 6: General discussion (Embargo until 31 October 2018)
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