- Cognition and comorbidity in ADHD: The role of methylphenidate and development
- Award date
- 29 June 2016
- Number of pages
- Document type
- PhD thesis
- Faculty of Social and Behavioural Sciences (FMG)
- Psychology Research Institute (PsyRes)
Information on the potential persistency of the effects of MPH for the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) is scarce, while in 2012, approximately 80,000 children and adolescents were treated with MPH in The Netherlands only. Therefore, the central objective of this dissertation was to determine whether MPH treatment during brain development leads to cognitive alterations. Other questions revolved around this assumption and served to improve the understanding of cognition and affective comorbidity in ADHD, and the role of stimulant use and development.
Specifically, we investigated whether the cognitive effects of MPH are persistent after treatment discontinuation in children, but not adults with ADHD (the ePOD trial described in Chapter 5). With the pre-treatment data of the ePOD trial, we addressed whether prior stimulant use is related to depressive and anxiety comorbidity (Chapter 4). Furthermore, we described a meta-analysis evaluating whether the cognitive effects of acute MPH depend on age (Chapter 3). We also examined the age-relationship of cognitive dysfunctions (Chapter 2), and of depressive and anxiety comorbidity in ADHD (Chapter 4). In both cases we excluded a potential influence of prior stimulant treatment in order to determine the actual nature of cognition and comorbidity. Last, test-retest reliabilities of experimental cognitive tests commonly used in research on developmental disorders were provided (Chapter 6).
- Please note that the section 'Acknowledgements | Dankwoord' is not included in this download version of the thesis.
Thesis (Embargo until 29 June 2018)
Chapter 2: Cognition in stimulant treatment-naïve boys and men with ADHD: an age perspective (Embargo until 29 June 2018)
Chapter 4: Comorbid depressive and anxiety symptoms in children and adolescents with ADHD: Impact of prior stimulant use (Embargo until 29 June 2018)
Chapter 5: Differences in persistent effects of methylphenidate on cognition in children and adults? A randomized, placebo-controlled trial (Embargo until 29 June 2018)
Chapter 6: Serial assessment with experimental cognitive tests in typically developing children and adults: Test-retest reliability and reliable change (Embargo until 29 June 2018)