M.J.T.F.D. Vrancken Peeters
Part 2 continued with a radioguided method, freehand-SPECT, to improve intraoperative navigation towards radioactively stained lesions. Freehand-SPECT was used to guide preoperatively ¹²⁵I-targeted 99mTc-albumin nanocolloid administrations used for the SN procedure and in a different study during breast cancer surgery.
Part 3 was about the consequences of the relatively new indications for SN procedures in recurrent breast cancer and the role of SPECT/CT imaging for this these procedures. This evaluation demonstrated that the current SN protocols for the new indications (recurrent breast cancer and neoadjuvant systemically treated breast cancer) that receive a SN procedure were inadequate. Further optimisation of institutional protocols may lead to more adequate patient tailored handling for the SN procedure. We conclude that a standard SPECT/CT scan after non-visualisation on planar imaging is not as useful as previously was assumed. Fortunately, intraoperative SN identification rates remain high for patients with non-visualisation when primary surgery was performed.
Thesis (complete) (Embargo until 27 May 2018)
Chapter 2: Heading towards radioactive seed localisation in non-palpable breast cancer surgery? A meta-analysis (Embargo until 27 May 2018)
Chapter 3: Surgical experience with intraoperative gamma cameras (Embargo until 27 May 2018)
Chapter 4: Simultaneous use of an ¹²⁵I-seed to guide tumour excision and 99mTc-nanocolloid for sentinel node biopsy in non-palpable breast-conserving surgery (Embargo until 27 May 2018)
Chapter 5: Improved accuracy and reproducibility using a training protocol for freehand-SPECT 3D mapping in radioguided surgery (Embargo until 27 May 2018)
Chapter 6: Radioguided Seed Localisation for breast cancer excision: an ex-vivo specimen-based study to establish accuracy of a freehand-SPECT device in predicting resection margins (Embargo until 27 May 2018)
Chapter 8: Intraoperative 3D navigation for single or multiple ¹²⁵I-seed localisation in breast-preserving cancer surgery (Embargo until 27 May 2018)
Chapter 9: The current status of augmented reality in nuclear medicine and molecular imaging: a literature overview (Embargo until 27 May 2018)
Chapter 10: The hidden sentinel node in breast cancer: reevaluating the role of SPECT/CT and tracer reinjection (Embargo until 27 May 2018)
Chapter 11: Radioguided surgery of non-palpable breast lesions: radio occult lesion localisation (ROLL) (Embargo until 27 May 2018)
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