- On human dendritic cell subsets harnessing cytotoxic T-cell responses
E.C. de Jong
- Award date
- 15 October 2015
- Number of pages
- Document type
- PhD thesis
- Faculty of Medicine (AMC-UvA)
In this work we explore the function of different dendritic cell (DC)-derived molecules in the induction of CTL responses. In chapter two we compare the capacity of two major human skin DC subsets to induce CTL responses, and we study which T-cell differentiating molecules are critical. In chapter three we investigate the comparative roles of human blood DC-derived IL-12 and IL-27 in promoting inflammatory and cytotoxic functions in CD8+ T-cells. In chapter four we compare the capacity of TLR3 and TLR8 stimulation in human blood-derived DCs to promote CTL responses through the induction CTL-promoting molecules as defined in the earlier chapters of this thesis. Furthermore, we investigate what signalling events are critically involved in the induction of these CTL-promoting molecules. In chapter five the CTL-inducing capacity of three major human blood DC subsets is compared and the role of several CTL-inducing factors further analysed. Finally, in chapter 6 we discuss how our results fit in and complement current knowledge about DC/T-cell interactions specifically directed at CTL differentiation.
- Research conducted at: Universiteit van Amsterdam
Thesis (complete) (Embargo until 15 October 2017)
Chapter 4: Differential activation of p38 regulates the capacity of CD1c+ DCs to promote cytotoxic T-cell responses (Embargo until 15 October 2017)
Chapter 5: dsRNA differentially primes CD141+ and CD1c+ dendritic cells to promote CTLs and Th1-cells (Embargo until 15 October 2017)
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