- Status epilepticus, blood-brain barrier disruption, inflammation, and epileptogenesis
- Epilepsy & Behavior
- Pages (from-to)
- Document type
- Faculty of Science (FNWI)
Faculty of Medicine (AMC-UvA)
- Swammerdam Institute for Life Sciences (SILS)
Over the last 15 years, attention has been focused on dysfunction of the cerebral vasculature and inflammation as important players in epileptogenic processes, with a specific emphasis on failure of the blood-brain barrier (BBB; Fig. 1) (Seiffert et al., 2004; Marchi et al., 2007; Oby and Janigro, 2006; van Vliet et al., 2014; Vezzani et al., 2011) [3-7]. Here, we discuss how the BBB is disrupted as a consequence of SE and how this BBB breakdown may be involved in epileptogenesis. This article is part of a Special Issue entitled "Status Epilepticus".
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